The New Orleans team faces a plague outbreak and Special Agent DiNozzo comes to help. Abby Sciuto, Leon Vance, and Carol Wilson assist.
- The first appearance of Leon Vance (Rocky Carroll) and Abby Sciuto (Pauley Perrette) in this episode from the main NCIS.
Loretta: My mother always said, "Look both ways before crossing." Now I realize she meant physically and metaphorically.
Sebastian: Uh, well, let's dive in. Ms.Wilson, feel free to get acquainted with my equipment. Uh, no. Well, I wasn't (clears throat) I wasn't trying to suggest that you actually...
|Dwayne Cassius Pride||Scott Bakula||Senior Special Agent in charge of the NCIS New Orleans office, NCIS|
|Christopher LaSalle||Lucas Black||Special Agent, New Orleans Office, NCIS|
|Meredith Brody||Zoe McLellan||Special Agent, New Orleans Office, NCIS|
|Sebastian Lund||Rob Kerkovich||Forensic Specialist, Jefferson Parrish Coroner's office|
|Dr. Loretta Wade||C. C. H. Pounder||Medical Examiner, Jefferson Parrish Coroner's office|
|Leon Vance||Rocky Carroll||NCIS Director|
|Abigail Sciuto||Pauley Perrette||NCIS Chief Forensic Specialist|
|Carol Wilson||Meredith Eaton||Scientist specializing in illness prevention|
|Anthony DiNozzo||Michael Weatherly||Senior Special Agent NCIS MCRT|
|Lara Hardling||Annika Marks|
|Louanne Bates||Erika Alexander||Navy Commander whoes officers are dying of the plague.|
|Michael Hufcutt||James Eckhouse||Doctor and killerwho made the new deadly strain of the plague.|
|Linus Waren||Andre Shanks|
|Katie the Bartender||Dacia Fernandez|
|Lewis Lang||Jimmy Gonzales||Navy Lieutenant|
|Lewis Collier||Nickolas James||
|Melora Haley||Nicole Barre||
Doctor working to track the plague.
|Diggs||Ross Britz||Navy Engin infected with the plague|